Severe allergic reaction — highest urgency.
CALL 911 IMMEDIATELY
Stop the infusion — discard current bag, hang new saline (no additives) through existing IV line
Administer epinephrine 0.3mg IM (auto-injector) to outer thigh
Place patient supine with legs elevated (unless respiratory distress)
Monitor airway — be prepared to assist ventilation
Start high-flow oxygen if available
Note time of epinephrine administration for EMS
Second dose of epinephrine after 5 minutes if no improvement
Stay with patient until EMS arrives — do not leave unattended